If you’re craving a pasta dish that’s bold, rich, and satisfying, you’re in for a treat. This Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce isn’t just a mouthful to say—it’s a mouthful of flavor. With juicy Cajun-seasoned chicken, a garlicky butter base, and a luscious Parmesan cream sauce, this recipe brings the heat and the comfort you need all in one pan.
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🔥 Why This Recipe Works for You
Whether it’s a busy weeknight or you’re planning a cozy dinner for two, this recipe checks all the boxes:
- One-pan simplicity for easy cleanup
- Big bold flavors thanks to the Cajun seasoning
- Comforting creamy texture that coats every bite
- Customizable with vegetables, spice levels, or even swapping the protein
🛒 Ingredients You’ll Need
For the Cajun Chicken:
- 2 large chicken breasts, sliced into strips
- 2 tablespoons Cajun seasoning
- Salt and black pepper to taste
- 2 tablespoons olive oil
For the Garlic Butter Base:
- 4 tablespoons unsalted butter
- 5 garlic cloves, minced
For the Creamy Parmesan Sauce:
- 1 cup heavy cream
- 1 cup grated Parmesan cheese
- 1/2 teaspoon red pepper flakes (optional)
- 1/2 teaspoon paprika
- Salt and black pepper, to taste
For the Pasta:
- 12 oz penne pasta, cooked al dente
- 1/2 cup reserved pasta water
Optional Add-Ins:
- 1 cup baby spinach
- 1/2 cup cherry tomatoes, halved
- Chopped parsley for garnish
🍳 Step-by-Step Instructions
1. Season and Cook the Chicken
- In a bowl, toss the chicken strips with Cajun seasoning, salt, and pepper.
- Heat olive oil in a large skillet over medium-high heat.
- Sear the chicken for 4–5 minutes per side until golden and cooked through.
- Remove and set aside.
2. Make the Garlic Butter Base
- In the same skillet, reduce heat to medium and melt the butter.
- Add minced garlic and sauté until fragrant, about 1 minute.
3. Create the Creamy Parmesan Sauce
- Stir in the heavy cream and bring to a light simmer.
- Add grated Parmesan cheese, paprika, red pepper flakes (if using), and stir.
- Season with salt and pepper to taste.
4. Combine It All
- Add the cooked penne to the skillet.
- Stir in reserved pasta water to loosen the sauce if needed.
- Toss in the cooked chicken.
- Add spinach and cherry tomatoes if using. Stir until everything is coated.
5. Garnish and Serve
- Sprinkle fresh parsley on top.
- Serve hot with extra Parmesan on the side.
🍽️ Pro Tips to Elevate Your Cajun Chicken Penne
- Want more spice? Add a pinch of cayenne or a dash of hot sauce.
- Richer flavor? Use half-and-half cream for a lighter version or double cream for ultra richness.
- Add veggies like bell peppers or mushrooms to pack in nutrition and texture.
- Swap proteins with shrimp or sausage for variety.
🧊 How to Store and Reheat
- Store leftovers in an airtight container for up to 3 days in the fridge.
- Reheat gently on the stovetop with a splash of cream or milk to loosen the sauce.
❓ FAQs – Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce
Can I make this ahead of time?
Yes! Prepare everything except the pasta and store separately. Combine and heat when ready to serve.
What can I substitute for heavy cream?
Half-and-half, coconut cream, or even cream cheese with milk can be used.
Is this dish gluten-free?
Use gluten-free penne pasta to make it suitable for gluten-sensitive diets.
✅ Final Thoughts: Flavor Worth Craving
You don’t need to be a chef to create something extraordinary. This Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce brings restaurant-quality flavor straight to your table—no reservations required. It’s rich, spicy, creamy, and utterly satisfying. Once you try it, you’ll keep coming back for more.
Ready to impress yourself and your guests? Make this tonight and taste why Cajun chicken pasta has become a new classic!